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In Ala40Thr variant, the frequency of Thr allele and the number ofsubjects with Thr allele were higher in T2D patients compared to non-diabetic subjects.Patients with Thr allele showed earlier age at diagnosis of diabetes, higher prevalence ofhypertension and lower insulin sensitivity compared to those without the allele (Tamai et al.,2006). The phytoestrogens bind to estrogen receptors in the bodyand fool the body into acting as if it had received more estrogen. The women were followed for up to eighteen years and themen for up to twelve years.

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The results by ethnicity showed that theassociation between GST M1 null genotype and risk for primary open angle glaucoma wasstatistically significant in East Asians but not in Caucasians and Latin Americans. vaso-constriction, central and peripheral sympatheticstimulation, release of aldosterone and Adr fromadrenals, renal actions promoting salt and waterreabsorption, central actions like thirst, vasopressinrelease and growth-promoting actions on heartand blood vessels are blocked.

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